Archives 2019

HIV Treatment Turns The Corner – Is Prevention Next? What Then?

HIV research is an area that has revitalized R&D in the therapeutic category of virology. Clearly, the severity and wide range of HIV infection and AIDS presented a worldwide public health crisis that triggered a strong urgency for scientific progress in the category. Pharmaceutical firms R&D is now delivering answers, and momentum is increasing. Major advances forecast a vastly different picture of HIV infection in the future than was the case a few decades ago. In some parts of the world, HIV is now considered akin to a chronic disease.

But the virus is formidable, inherently mutability, thus still presents the need for new drugs and new classes, as well as simpler regimens to improve compliance; and there is a debate about what course and measures to take if preventive medication for HIV infection diminishes safe sex practice.

Medmeme, LLC., a global leader in comprehensive, integrated medical and science information database platforms, has released a new syndicated TrendsmemeTM Report: Virology. The report covers, in detailed documentation, charts, and graphs, the activities of pharmaceutical companies, the status and potential of new drugs (and vaccines) revealing the dominant players in R&D and the marketplace as well as relevant issues and developments in HIV treatment. It explains the broader, current status of the virology therapeutic area and major trends driving change and influencing R&D success (including for HCV and HPV). Acquisition of smaller firms with promising products in pipelines is bolstering competitive positioning of major players in efforts to deliver new HIV treatments.

Companies discussed in the report are classified by the character and strength of their involvement with HIV treatments (and other virology topics). They include, among others: Abbott Laboratories, Bristol-Myers Squibb, GeoVax, Gilead Sciences, GlaxoSmithKline, Inovio, Jannsen, Merck & Co, Pharmasett, Pfizer, Progenics Pharmaceuticals, Roche, Sangamo BioSciences, and Vertex Pharmaceuticals.

The most recommended line of treatment for HIV is through highly active antiretroviral therapy (HAART), which involves taking a regimen of three or more anti-HIV drugs from at least two different drug classes. Gilead enjoys a wide lead over other companies in its sales of anti-HIV drugs. The company created a worldwide network of groups to bolster its technology and innovation that has lead to advantageous positioning. Its new Quad Pill, a once-daily single tablet regimen of elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate for treatment of HIV-1 infection is set for an FDA review target date of August 27, 2012.

Despite the amount of research and development for HIV treatment, there is still great opportunity for companies to bring more to the table in terms of safe, effective medications that enhance longevity and quality of life. The goal that has yet to be achieved is development of safe and effective vaccines. The National Institutes of health (NIH) lists more than 5,000 HIV/AIDS clinical trials in all phases intended to address unmet needs.

A total of 88 drugs27 of which are vaccinesin company HIV/AIDS pipelines are in clinical trials or waiting for FDA approval, according to a recent industry group report. And scientific data from the Medmeme database reports that nearly 200 papers were presented at medical meetings worldwide on the topic of HIV vaccines in each of the three most recent years. Of the leading anti-HIV pharmaceutical manufacturers, GlaxoSmithKline and Merck both sponsored a major number of these presentations. The Medmeme database indicates both companies are also dominate in the number of current clinical trials, as listed by NIH.

The syndicated TrendsmemeTM Report : Virology can be purchased separately, or, along with other MedMeme reports, at discounted pricing.


Surviving HIV AIDS

This page is dedicated to my story of HIV and AIDS and how I feel that I have survived. Anything that I say is not to be construed as medical advice. I am not a person in the medical community. I only provide my story and thoughts as informational.

I was diagnosed with HIV/AIDS in 1984 and as such am a long term survivor. I have been very close to death on a couple of occasions; however, I have rebounded each time. In 1985 I had lymphadenopathy which is a swelling of the lymph nodes and it continued on for three month. I was in bed much of the time counting my blessing and being thankful for the good things in my life.

In 1985 I also had oral thrush, strep B, and oral herpes all at the same time in my mouth and throat. It was very difficult to swallow and had to gargle with a drug like novacaine. Here again it was about three months until I recovered from this massive infection.

In 1986 I came down with shingles or herpes zoster. This is an excruciatingly painful disease. The infection started from a nerve in my back and spread out from there to my belly and down into my groin. It also went up my chest and down my left arm. They put you on drugs for pain but nothing can stop it – it just makes you care less about it. With good medical care I did recover in about 4 months without any scars.

My last big opportunistic infection was histoplasmosis. This bug gets into the lungs, blood stream, bone marrow and also possible the brain. Without immediate treatment you will begin losing weight from all of the fever sweating that you do. I lost about 38 pounds in a months time. Each morning I got up on the scale and each time more weight had disappeared. I was placed in the hospital for about a week to start my recovery. The drug was awful. Unfortunately when I got well so did my weight. This was in 1995 and except for prostate cancer I have been in pretty good condition.

If you have had sex with unknown partners, remember everyone they have had sex with is a possible exposure to HIV. Anonymous testing is available and should be done as soon as possible. The site below will take you to a place that you can test via mail order. Otherwise, look up a Aids Support Organization and find out where testing is available.

The below chip will take you to a site where, if you should want to, you can purchase a home test kit. They will provide you all the directions and how to have the test analyzed.

A great site to look into, particularly if your local and live in Hawaii is “dacoconutwireless.com.” This site was created by a local man who has put a lot of work into HIV AIDS. Looking at it may inspire others to do the same.

Tags: AIDS, HIV, Long Term Survivor, Robert Zimmer, Survival AIDS